Old Folks’ Swine Flu Immunity

Via Jason Kottke, I see the first plausible explanation for the otherwise odd fact that seniors, who are typically among the most susceptible to death from flu, are strangely immune to the “swine flu” epidemic.

Confirming the first impressions of many American and Mexican doctors, federal health officials said on Wednesday that people born before 1957 appear to have some immunity to the swine flu virus now circulating. Tests on blood serum from older people showed that they had antibodies that attacked the new virus, Dr. Daniel Jernigan, chief flu epidemiologist at the Centers for Disease Control and Prevention, said in a telephone news conference.

[…]

The protection theory, Dr. Jernigan explained, is that from 1918 to 1957, all circulating seasonal type-A flus were weakened descendants of the 1918 Spanish flu, which was an H1N1, as the current swine is. (All flus are named for the shapes of hemagglutinin and neuraminidase displayed on the virus’s shell. Hemagglutinin is sometimes called the “spike”: the virus uses to enter a cell, while neuraminidase is the “helicopter blade” that chops off receptors, allowing newly made virus to escape.)

Then in 1957, an H2N2, the Asian flu, emerged and displaced it. It was replaced in 1968 by the H3N2, called Hong Kong flu, which has persisted as a seasonal strain. A different and milder H1N1 emerged in 1977. It was isolated in China but is called the Russian flu because of a suspicion it escaped from a Soviet laboratory. That H1N1, the 1968 H3N2 and a B strain have all circulated in humans ever since, and the seasonal flu shot is aimed at them.

Fascinating.

Photo: Getty Images

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James Joyner
About James Joyner
James Joyner is Professor and Department Head of Security Studies at Marine Corps University's Command and Staff College and a nonresident senior fellow at the Scowcroft Center for Strategy and Security at the Atlantic Council. He's a former Army officer and Desert Storm vet. Views expressed here are his own. Follow James on Twitter @DrJJoyner.

Comments

  1. Boyd says:

    Old folks?!

    Damn punk kids these days, don’t respect their elders. *grumble* *grumble*

    GIT OFFA MY LAWN!

  2. PD Shaw says:

    Can I gain immunity with a blood transfusion from an old person?

    And when did being born in 1956 become old? Is 53 the new 83?

  3. James Joyner says:

    Heh. Well, most of those born before 1956 and still living are over 65, no?

    Besides, the counterintuitive and thus interesting thing is the immunity of seniors, not the fate of middle-agers.

  4. Dave Schuler says:

    Well, most of those born before 1956 and still living are over 65, no?

    That’s an interesting question and I don’t know the answer to it. Rephrasing it is the number of people born between 1944 and 1956 greater than the number of people born prior to 1944?

    Let’s look at the U. S. only. Judging by this, I’d say no. According to the table the number of whites in the U. S. born between 1944 and 1956 and still living is about 60 million while the number of whites in the U. S. still living born before 1944 is less than 25 million.

  5. Dave Schuler says:

    BTW, if the speculation is true it suggests that the level of threat that the disease poses to the populations of different countries may be very different. For example, only a small fraction of the population of the KSA was born before 1956.

  6. sam says:

    The great killing Spanish flu of 1918 showed similar pathology:

    The Death Rate Curve
    The curve of influenza deaths by age has, historically, for at least 150 years, been U-shaped, with death peaks in the very young and the very old, with a comparatively low number of deaths at all ages in between.

    In contrast, age-specific death rates in the Spanish flu pandemic showed a distinct pattern that has not been documented before or since: a “W-shaped” curve, similar to the familiar U-shaped curve, but with the addition of a third (middle) distinct peak of deaths in young adults who were between 20 and 40 years of age.

    Influenza and pneumonia death rates for those 15 to 34 years of age in 1918—1919, for example, were 20 times higher than in previous years. Overall, nearly half of the influenza-related deaths in the 1918 pandemic were in young adults who were 20 to 40 years of age, a phenomenon unique to that pandemic year.

    The Spanish flu pandemic is also unique among influenza pandemics in that absolute risk of influenza death was higher in those who were younger than 65 years of age than in those who were greater than 65 years of age. People who were younger than 65 accounted for 99 percent of all excess influenza-related deaths in 1918—1919. In comparison, those who were older than 65 accounted for 36 percent of all excess influenza-related deaths in the 1957 H2N2 pandemic and 48 percent in the 1968 H3N2 pandemic.